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Total synthesis of gibbilimbols A-D
James R Vyvyan1, Christian L Holst, Allison J Johnson
1Department of Chemistry, Western Washington University, Bellingham, Washington 98225-9150, USA. vyvyan@chem.wwu.edu
The Journal of Organic Chemistry
|April 2, 2002
Abstract:
Gibbilimbols A-D (1-4) were synthesized in 32-49% yield over four steps from commercially available starting materials. A copper-catalyzed coupling of 4-methoxyphenylmagnesium bromide with various unsaturated alkyl bromides was the key step in assembling the (long-chain alkyl)phenol skeleton.