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Updated: Oct 1, 2026

Experimental Model to Evaluate Resolution of Pneumonia
Published on: February 17, 2023
[A case of chronic hypersensitivity pneumonia with elevation of serum SP-D and KL-6]
Tetsuro Ohnishi1, Gen Yamada, Hiroshi Tanaka
1Third Department of Internal Medicine, University School of Medicine, Sapporo, 060-8543, Japan.
Abstract:
A 73-year-old woman suffering from dyspnea on effort and chronic cough was admitted to our hospital. Chest computed tomography disclosed ground-glass opacities, irregular linear opacities and honeycombing distributed predominantly in the subpleural area. The serum levels of SP-D and KL-6 rose to 889 ng/ml, 1,755 U/ml, respectively. These findings indicated idiopathic pulmonary fibrosis. However, the number of lymphocytes and the CD4/CD8 ratio in the BAL fluid were elevated. Transbronchial lung biopsy specimens demonstrated alveolitis with granuloma formation. The evidence that she had lived in a house with a heavy fungal growth and that tests of precipitation in response to Penicillium corylophilum were positive confirmations of a diagnosis of chronic hypersensitivity pneumonia.
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