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[A case of allopurinol-induced muscular damage in a chronic renal failure patient]
Hiroyuki Terawaki1, Takahide Suzuki, Kazunobu Yoshimura
1Department of Nephrology, Department of Orthopedics, Sakura National Hospital, Chiba, Japan.
Abstract:
A 73-year-old woman with chronic renal failure developed generalized muscular weakness and pain 6 days after the start of allopurinol treatment(200 mg/day). Routine laboratory tests revealed elevated levels of serum creatine kinase, and the patient was clinically diagnosed as rhabdomyolysis, due probably to severe myositis. A high level of serum oxipurinol, the chief active metabolite of allopurinol, was also revealed. The muscular weakness was relieved in seven weeks with intermittent hemodiafiltration.
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