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[Left and right ventricular function in acromegalic patients].

R Twardowski1, T Mandecki, K Mizia-Stec

  • 1II Katedra i Klinika Kardiologii Sl. AM w Katowicach.

Polskie Archiwum Medycyny Wewnetrznej
|April 3, 2002
PubMed
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Acromegaly patients show increased ventricular arrhythmias and impaired heart diastolic function, even without hypertension. These cardiovascular changes are linked to left ventricular hypertrophy and disease duration, highlighting endocrine-cardiac system interactions.

Area of Science:

  • Cardiology
  • Endocrinology
  • Internal Medicine

Background:

  • Acromegaly, caused by excess growth hormone, is linked to cardiovascular issues.
  • Understanding these links is crucial for managing acromegaly patients.

Purpose of the Study:

  • To evaluate cardiac function in acromegaly patients using Holter monitoring and echocardiography.
  • To assess the prevalence of arrhythmias and diastolic dysfunction.

Main Methods:

  • 28 acromegaly patients (15 with hypertension) underwent 24-hour Holter monitoring and echocardiography.
  • Control groups included 20 essential hypertension patients and 20 healthy normotensive subjects.

Main Results:

  • 65% of acromegaly patients had ventricular premature complexes, significantly more than controls.

Related Experiment Videos

  • Left ventricular mass was elevated, and diastolic filling was impaired in 89% of acromegalics.
  • Arrhythmias correlated with left ventricular hypertrophy and disease duration.

    • Conclusions:

    • Acromegaly patients frequently exhibit left ventricular hypertrophy and diastolic dysfunction, independent of hypertension.
    • Ventricular arrhythmias in acromegaly are associated with left ventricular hypertrophy.
    • Cardiovascular complications are significant in acromegaly, emphasizing the endocrinic-cardiac link.