Membranous glomerulonephropathy with crescents

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Updated: Oct 21, 2026

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

G D Nicholson, U F Amin, G A Alleyne

    Clinical Nephrology
    |November 1, 1975
    PubMed

    Insights

    Idiopathic membranous glomerulonephropathy typically presents with basement membrane thickening. This case shows co-existing cellular crescents, indicating a rapidly progressive form of the kidney disease.

    Area of Science:

    • Nephrology
    • Pathology
    • Renal Medicine

    Background:

    • Idiopathic membranous glomerulonephropathy (IMGN) is a common cause of nephrotic syndrome in adults.
    • IMGN is characterized by diffuse thickening of the glomerular basement membrane due to immune complex deposition.
    • The typical presentation involves gradual onset of proteinuria and edema.

    Observation:

    • A patient with a four-year history of mild ankle edema presented with rapidly progressive renal function decline.
    • Renal biopsy revealed histological features of IMGN.
    • Atypical glomeruli with cellular epithelial crescents were also observed alongside diffuse basement-membrane thickening.

    Findings:

    • The co-existence of typical IMGN features and cellular crescents suggests a more aggressive disease course.
    • The presence of crescents indicates severe glomerular injury and potential for rapid loss of kidney function.
    • This histological pattern represents a diagnostic challenge in differentiating IMGN from other crescentic glomerulonephritides.

    Implications:

    • This case highlights the importance of thorough histological examination in diagnosing kidney diseases.
    • Recognizing atypical features in IMGN is crucial for predicting prognosis and guiding treatment.
    • Further research may elucidate the mechanisms behind crescent formation in IMGN and its therapeutic implications.

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