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Anomalous (preduodenal) portal vein: autosomal recessive mutation in AKR/J mice
1Department of Radiation Biology and Medical Genetics, Graduate School of Medicine, Osaka University, Suita, Japan.
Background And Purpose:
Anomalous (preduodenal) portal vein was found in AKR/J mice. It is a rare congenital malformation in humans, and to the authors' knowledge, has never been reported in laboratory animals. Morphology, clinical signs of disease, and heritability of this anomaly were examined.
Methods:
Fifty-three strains of inbred mice (6,026 mice) in our mouse colony were examined for preduodenal portal vein and its association with clinical signs of disease (vomiting or abdominal pain) and other anomalies. Heritability also was tested by use of cross-backcross matings of AKR/J mice with clinically normal PT mice.
Results:
The portal vein was found at the ventral side of the duodenum in most (98%) AKR/J mice, whereas it ran at the dorsal side of the duodenum in 52 other inbred mouse strains in our mouse colony. Clinical signs of disease and other congenital anomalies were not detected in this strain of mice, although position has a high association with other congenital anomalies in humans. Heritability testing of this anomaly in AKR/J mice indicated single autosomal recessive inheritance.
Conclusions:
Preduodenal portal vein found in AKR/J mice is a single autosomal recessive mutation, but is not associated with clinical signs of disease and other congenital malformations.
Insights
A rare congenital anomaly, preduodenal portal vein, was identified in AKR/J mice. This genetic mutation is inherited in an autosomal recessive pattern and does not cause disease symptoms.
Area of Science:
- Veterinary Anatomy
- Developmental Biology
- Genetics
Background:
- Preduodenal portal vein is a rare congenital malformation in humans.
- This anomaly has not been previously reported in laboratory animal models.
- AKR/J mice were identified with this rare vascular anomaly.
Purpose of the Study:
- To investigate the morphology and inheritance of preduodenal portal vein in AKR/J mice.
- To determine if this anomaly is associated with clinical signs of disease or other congenital defects.
- To establish a model for studying preduodenal portal vein in a laboratory setting.
Main Methods:
- Examination of 53 inbred mouse strains (6,026 mice) for preduodenal portal vein.
- Assessment of clinical signs (vomiting, abdominal pain) and other anomalies in affected mice.
- Heritability testing using cross-backcross matings between AKR/J and PT mice.
Main Results:
- Preduodenal portal vein was present in 98% of AKR/J mice, contrasting with other strains where it was dorsal.
- No clinical signs of disease or other congenital anomalies were observed in AKR/J mice with the anomaly.
- Heritability analysis indicated a single autosomal recessive inheritance pattern for the preduodenal portal vein.
Conclusions:
- The preduodenal portal vein in AKR/J mice represents a single autosomal recessive mutation.
- This specific genetic mutation does not appear to cause disease or other malformations in this mouse model.
- AKR/J mice provide a valuable model for studying the genetics and potential long-term effects of preduodenal portal vein.
