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The efficacy of valsartan in essential hypertension and its effects on left ventricular hypertrophy

Haşim Mutlu1, Hakan Ozhan, Bariş Okçün

  • 1Istanbul University, Institute of Cardiology, Turkey. hasimmutlu@hotmail.com

Blood Pressure
|April 3, 2002
PubMed

Insights

Valsartan effectively controls hypertension and reduces cardiac structural changes like left ventricular hypertrophy (LVH). This study shows valsartan favorably influences cardiac structure in hypertensive patients by decreasing interventricular septum and posterior wall thickness.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Hypertension is a significant risk factor for left ventricular hypertrophy (LVH).
  • Angiotensin-converting enzyme (ACE) inhibitors and angiotensin-II receptor blockers have shown potential in reducing LVH.

Purpose of the Study:

  • To assess the efficacy of valsartan on echocardiographic variables of LVH in patients with mild to moderate hypertension.

Main Methods:

  • A study involving 30 patients with mild to moderate hypertension.
  • Echocardiographic assessment of left ventricular hypertrophy (LVH) parameters.

Main Results:

  • Valsartan demonstrated effectiveness in controlling hypertension.
  • Significant reductions were observed in interventricular septum and posterior wall thickness.
  • Left ventricular mass decreased significantly, indicating a reduction in LVH.

Conclusions:

  • Valsartan favorably influences cardiac structure in hypertensive patients.
  • The drug effectively reduces echocardiographic indices of left ventricular hypertrophy (LVH).

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