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Related Experiment Videos

Controlled-release naproxen using micronized ethyl cellulose by wet-granulation and solid-dispersion method.

Zabed Iqbal1, Almas Babar, Muhammad Ashraf

  • 1Long Island University, Brooklyn, NY, USA.

Drug Development and Industrial Pharmacy
|April 3, 2002
PubMed
Summary
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This study developed controlled-release naproxen tablets using ethyl cellulose. Solid dispersion required less polymer and showed slightly better drug release compared to wet granulation.

Area of Science:

  • Pharmaceutical Technology
  • Drug Delivery Systems
  • Materials Science

Background:

  • Naproxen is a widely used nonsteroidal anti-inflammatory drug (NSAID).
  • Developing controlled-release formulations enhances therapeutic efficacy and patient compliance.
  • Ethyl cellulose (Ethocel) is a common hydrophobic polymer used for rate-controlling drug release.

Purpose of the Study:

  • To develop a controlled-release tablet dosage form of naproxen.
  • To evaluate the efficacy of ethyl cellulose as a rate-controlling polymer.
  • To compare the solid dispersion method with the conventional wet granulation method for naproxen controlled-release formulations.

Main Methods:

  • Formulation of naproxen tablets using ethyl cellulose via wet granulation and solid dispersion methods.

Related Experiment Videos

  • Comparative analysis of controlled-release dissolution profiles for both formulation methods.
  • Evaluation of polymer requirement and drug release percentages.

    • Main Results:

    • Both wet granulation and solid dispersion methods successfully produced controlled-release naproxen formulations.
    • The solid dispersion method required 33% less ethyl cellulose polymer for a desired release profile compared to wet granulation.
    • Cumulative drug release was 88% for the solid dispersion formulation versus 84% for the wet granulation formulation.

    Conclusions:

    • Solid dispersion is a more efficient method for developing naproxen controlled-release tablets using ethyl cellulose.
    • The developed formulations demonstrate desirable controlled-release properties.
    • Optimization of polymer concentration is crucial for achieving targeted drug release profiles.