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New triterpenoidal alkaloids from Buxus sempervirens.

Athar Ata1, Samina Naz, M Iqbal Choudhary

  • 1Department of Chemistry, The University of Winnipeg, Manitoba, Canada. chemistry@c-h.uwinnipeg.ca

Zeitschrift Fur Naturforschung. C, Journal of Biosciences
|April 3, 2002
PubMed
Summary

Researchers identified two new triterpenoidal alkaloids from Turkish Buxus sempervirens roots. One compound showed antibacterial activity against human pathogens and weak phytotoxicity.

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Area of Science:

  • Phytochemistry
  • Natural Products Chemistry
  • Pharmacognosy

Background:

  • Buxus sempervirens (common boxwood) is a plant species with a history of traditional medicinal uses.
  • Triterpenoidal alkaloids are a class of natural compounds known for diverse biological activities.
  • Turkish flora represents a rich source of novel phytochemicals.

Purpose of the Study:

  • To isolate and characterize novel and known phytochemicals from the ethanolic root extract of Turkish Buxus sempervirens.
  • To elucidate the chemical structures of isolated compounds using spectroscopic methods.
  • To evaluate the biological activities of the isolated compounds, including antibacterial and phytotoxic effects.

Main Methods:

  • Phytochemical investigation involving solvent extraction (ethanolic extract).

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  • Isolation of compounds using chromatographic techniques.
  • Structure elucidation through extensive spectroscopic analyses (e.g., NMR, MS).
  • Bioactivity screening, including antibacterial assays against human pathogens and phytotoxicity tests using Lemna minor.

    • Main Results:

    • Isolation and identification of two new triterpenoidal alkaloids: (+)-16a, 31-diacetylbuxadine (1) and (-)-Nb-demethylcyclomikuranine (2).
    • Identification of three known natural products: (-)-cyclomikuranine (3), (-)-cyclobuxophylline-K (4), and (+)-buxaquamarine (5), reported for the first time in this Buxus species.
    • Compound 1 demonstrated significant antibacterial activity against human pathogenic bacteria.
    • Compound 1 exhibited weak phytotoxic activity against Lemna minor.

    Conclusions:

    • The study successfully identified novel triterpenoidal alkaloids from Turkish Buxus sempervirens, expanding the known chemical diversity of the genus.
    • The isolated compounds, particularly (+)-16a, 31-diacetylbuxadine, possess potential as sources for new antibacterial agents.
    • Further research into the pharmacological properties and mechanisms of action of these compounds is warranted.