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Laparoscopic fundoplication versus lansoprazole for gastro-oesophageal reflux disease. A pH-metric comparison
M Frazzoni1, A Grisendi, A Lanzani
1Department of Internal Medicine and Gastroenterology, S. Agostino Hospital, Modena, Italy. marziofrazzoni@hotmail.com
Background:
Treatment strategies that abolish abnormal reflux could prevent long-term complications of gastro-oesophageal reflux disease.
Aims:
To compare the efficacy of laparoscopic fundoplication and lansoprazole in abolishing abnormal reflux in patients with gastro-oesophageal reflux disease.
Patients:
Study population comprised 130 patients referred for possible antireflux surgery and with heartburn as the dominant symptom.
Methods:
After oesophageal manometric and pH-metric evaluation and detailed information 55 patients asked to undergo laparoscopic antireflux surgery while 75 chose a medical treatment regimen based on lansoprazole. Treatment efficacy was assessed by ambulatory oesophageal pH-monitoring.
Results:
All 55 patients who underwent fundoplication became free of heartburn: oesophageal pH-monitoring gave normal results in 85%. In patients treated with lansoprazole, at individualized daily dosages titrated to abolish both heartburn and abnormal acid reflux, normal pH-metric results were obtained in 96% of cases (p<0.05 vs surgically treated patients).
Conclusions:
Lansoprazole at individualized dosages was significantly more effective than laparoscopic fundoplication, in the short-term, in abolishing abnormal reflux in gastro-oesophageal reflux disease patients.