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Related Experiment Videos

Normal P50 gating in children with autism.

Chantal Kemner1, Bob Oranje, Marinus N Verbaten

  • 1Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, The Netherlands. c.kemner@psych.azu.nl

The Journal of Clinical Psychiatry
|April 3, 2002
PubMed
Summary

Children with autism show normal sensory filtering abilities, specifically in P50 gating, unlike individuals with schizophrenia. This suggests typical early inhibitory processes in autism.

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Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Clinical Psychology

Background:

  • Unusual sensory reactions in children with autism may stem from impaired sensory input filtering.
  • The P50 gating paradigm is a tool to measure sensory filtering.

Purpose of the Study:

  • To investigate sensory filtering in children with autism using the P50 gating paradigm.
  • To compare P50 suppression between children with autism and typically developing controls.

Main Methods:

  • Twelve children diagnosed with autism (autistic disorder or PDD-NOS) and 11 healthy controls participated.
  • P50 suppression was measured at the Cz electrode using the P50 gating paradigm.

Main Results:

  • No significant differences were observed in absolute P50 amplitudes between groups.

Related Experiment Videos

  • P50 suppression levels were comparable between children with autism and control children.

    • Conclusions:

    • The neuronal mechanisms underlying P50 generation are normal in children with autism.
    • Early inhibitory processes involved in P50 gating appear to be intact in autism.
    • These findings differentiate autism from schizophrenia, where sensory gating deficits are evident.