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Economic impact of cytomegalovirus in solid organ transplantation

C V Paya1

  • 1Mayo Medical School of Medicine, Rochester, Minnesota, USA. paya@mayo.edu

Transplant Infectious Disease : an Official Journal of the Transplantation Society
|April 3, 2002
PubMed

Insights

Cytomegalovirus (CMV) infection significantly increases costs in solid organ transplant patients. This is especially true for CMV-seronegative recipients receiving organs from CMV-seropositive donors, impacting program expenses.

Area of Science:

  • Transplantation immunology
  • Virology
  • Health economics

Background:

  • Cytomegalovirus (CMV) infection is a major complication in solid organ transplantation.
  • CMV infection contributes to morbidity, opportunistic infections, allograft rejection, and mortality.
  • The economic impact of CMV infection on transplant programs remains under-quantified.

Purpose of the Study:

  • To investigate the direct and indirect effects of Cytomegalovirus (CMV) infection on the costs associated with solid organ transplantation.
  • To provide evidence for the financial burden imposed by CMV in transplant recipients, particularly high-risk groups.

Main Methods:

  • Review of existing literature and cost-effectiveness analyses related to CMV infection in solid organ transplant recipients.
  • Analysis of cost data, focusing on specific patient populations such as CMV-seronegative recipients of seropositive allografts (D+/R-).

Main Results:

  • Accumulating evidence indicates a significant impact of CMV infection on transplantation program costs.
  • The D+/R- donor/recipient serostatus combination is particularly associated with increased costs.
  • CMV infection exacerbates the risk of opportunistic infections, contributing to additional healthcare expenditures and graft rejection.

Conclusions:

  • Cytomegalovirus (CMV) infection imposes a substantial financial burden on solid organ transplantation programs.
  • Targeted cost-containment strategies for CMV management are crucial, especially for high-risk patient cohorts.
  • Further research is warranted to fully elucidate the economic consequences of CMV in transplantation.

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