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Updated: Oct 1, 2026

The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rNAION)
Published on: November 20, 2016
Chlamydia pneumoniae seropositivity and the risk of nonarteritic ischemic optic neuropathy
Martin Weger1, Anton Haas, Olaf Stanger
1Department of Ophthalmology, Karl-Franzens University, Auenbruggerplatz 4, 8036 Graz, Austria. martin.weger@kfunigraz.ac.at
Objective:
To determine whether IgG antibodies to Chlamydia pneumoniae are associated with nonarteritic ischemic optic neuropathy (NAION).
Design:
Retrospective case-control study.
Participants:
The study cohort consisted of 71 consecutive patients with NAION and 71 controls matched for age and gender.
Main Outcome Measures:
Serum immunoglobulin G (IgG) antibody titers to Chlamydia pneumoniae.
Results:
Patients with NAION had significantly higher IgG antibody titers to C. pneumoniae compared with control subjects (IgG titer > or =1:128: 29 patients versus 15 controls, P = 0.017). The odds ratio for patients with an IgG titer > or =1:128 was 2.56 (95% confidence interval [CI], 1.2-5.5). Adjustment for arterial hypertension, diabetes mellitus, and myocardial infarction resulted in an odds ratio of 3.48 (95% CI, 1.3-9.6).
Conclusions:
Our results suggest that elevated titers of IgG antibodies to C. pneumoniae are associated with NAION.
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