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Plexiform spitz nevus.

B Clarke1, A Essa, R Chetty

  • 1Department of Pathology, Nelson R. Mandela School of Medicine, University of Natal, Private Bag 7, Congella 4013, Durban, South Africa.

International Journal of Surgical Pathology
|April 3, 2002
PubMed
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This study details a rare plexiform Spitz nevus variant in a pediatric patient. It highlights the importance of considering this diagnosis and its differential in similar clinical presentations.

Area of Science:

  • Dermatopathology
  • Oncology

Background:

  • Spitz nevi are melanocytic neoplasms often seen in children and young adults.
  • A rare plexiform variant of Spitz nevus was first described in 1999.

Observation:

  • A case of plexiform Spitz nevus occurred on the upper thigh of a 10-year-old boy.
  • Histological examination revealed epithelioid cell nodules in a plexiform pattern within the dermis.
  • Tumor cells showed eosinophilic cytoplasm, vesicular nuclei, prominent nucleoli, and focal intranuclear inclusions.

Findings:

  • The tumor was set in a myxoid stroma with lymphocytic and eosinophilic inflammation.
  • Melanin-containing spindle cells were occasionally present.
  • The differential diagnosis includes various melanocytic and nonmelanocytic lesions with plexiform or myxoid features.

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Implications:

  • Accurate histological diagnosis is crucial for differentiating plexiform Spitz nevus from other lesions.
  • This case adds to the literature on this rare variant, aiding future diagnostic efforts.
  • Understanding the histological spectrum of Spitz nevi is important for clinical management.