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[Hepatitis C and pregnancy].

L Alric1, N Costedoat, J C Piette

  • 1Service de médecine interne, pavillon Dieulafoy, hôpital Purpan, CHU, place du Docteur-Baylac, 31057 Toulouse, France. alric.L@chu-toulouse.fr

La Revue De Medecine Interne
|April 4, 2002
PubMed
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Hepatitis C virus (HCV) infection in pregnancy is better understood, with vertical transmission rates around 6%. Careful follow-up of mothers and infants is crucial for managing perinatal HCV infection.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Maternal-Fetal Medicine

Background:

  • Antenatal screening for Hepatitis C virus (HCV) is recommended for women with risk factors.
  • Viral replication confirmation via PCR is necessary for pregnant women with anti-HCV antibodies.
  • Pregnancy management and delivery modes are generally unaffected by HCV infection alone.

Purpose of the Study:

  • To elucidate the natural course of Hepatitis C virus (HCV) infection during pregnancy.
  • To determine the prevalence and factors influencing mother-to-child transmission of HCV.

Main Methods:

  • Review of existing literature on HCV in pregnancy.
  • Analysis of vertical transmission rates in HCV-monoinfected and HIV-coinfected women.
  • Discussion of screening protocols for infants born to HCV-positive mothers.

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Main Results:

  • HCV vertical transmission rates are approximately 6% in HCV-monoinfected women and 15% in HIV-coinfected women.
  • Infants born to HCV-positive mothers require HCV marker screening at 18 months postpartum.
  • Pregnancy is generally permissible for women with HCV due to low vertical transmission rates.

Conclusions:

  • Close monitoring of both mothers and newborns is essential for pregnancies affected by HCV.
  • Long-term follow-up of infants is necessary to evaluate the outcomes of perinatal HCV infection.
  • Antiviral treatment for HCV before pregnancy should be considered given new therapeutic strategies.