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[Fibrinogen (Fb) concentrations in patients with ischaemic heart disease undergoing coronary angiography]
I Goracy1, J Goracy, M Brykczyński
1Katedra Biochemii Klinicznej i Diagnostyki Laboratoryjnej Pomorskiej AM w Szczecinie.
Insights
Elevated plasma fibrinogen is linked to ischemic heart disease (IHD) risk. This study found no significant increase in fibrinogen with IHD severity but a decrease in patients with myocardial infarction history.
Area of Science:
- Cardiology
- Hematology
- Vascular Biology
Background:
- Hemostatic risk factors are increasingly implicated in ischemic heart disease (IHD) development.
- Elevated plasma fibrinogen levels are a known risk factor for IHD.
Purpose of the Study:
- To investigate the relationship between plasma fibrinogen levels and the severity of coronary artery disease.
- To assess plasma fibrinogen in patients undergoing coronary angiography.
Main Methods:
- 119 patients undergoing coronary angiography were categorized into five groups based on IHD severity.
- Groups included a control group (no significant lesions), single-vessel disease, multivessel disease (2-3 arteries), and a history of myocardial infarction.
- Plasma fibrinogen levels were measured and compared across groups; correlation with blood pressure was also analyzed.
Main Results:
- Plasma fibrinogen showed a non-significant increase in patients with single (3.9 g/l) and multivessel disease (4.0-4.1 g/l) compared to controls (3.7 g/l).
- Patients with a history of myocardial infarction exhibited significantly lower plasma fibrinogen levels (2.8 g/l) than controls (p < 0.05).
- Plasma fibrinogen levels demonstrated a positive correlation with blood pressure.
Conclusions:
- The study suggests a complex role for plasma fibrinogen in ischemic heart disease.
- While not directly correlating with disease severity in this cohort, findings support fibrinogen's involvement in IHD pathogenesis, particularly its association with blood pressure.
Abstract:
Increasing evidence suggests the role of hemostatic risk factors in the development of ischemic heart disease (IHD). A raised plasma fibrinogen has been related to increased risk of IHD. The aim of the study was to determine the relationship between plasma fibrinogen and the coronary vessels state based on the coronary angiogram. 119 patients undergoing coronary angiography were classified into 5 groups according the severity of IHD: Group 0 without significant atherosclerotic lesions (control group), Group 1 with single vessel disease, Groups 2, 3 with multivessel disease (two and three affected arteries, respectively) and Group 4 with positive history of myocardial infarction. A statistically nonsignificant rise in fibrinogen levels in Groups 1, 2, 3 (3.9 +/- 0.8 g/l, 4.0 +/- 0.9 g/l, 4.1 +/- 0.9 g/l, respectively) as compared to control Group 0 (3.7 +/- 0.7 g/l) was found. In Group 4 plasma fibrinogen was significantly lower (2.8 +/- 0.6 g/l) comparing to Group 0 (p < 0.05). In addition plasma fibrinogen was positively correlated with blood pressure. These results supports the role of raised plasma fibrinogen in the pathogenesis and development of IHD.