Pulmonary talc embolization

A young woman with a history of drug abuse rapidly developed cor pulmonale, restrictive pulmonary defect, low diffusion capacity, and a suggestion of left ventricular dysfunction. She died from complications after a lung biopsy. Microscopic examination showed talc granulomas and arteritis. Some form of closed biopsy is probably safer, and trial of corticosteroid therapy seems warranted for this diagnosis. Talc ia a dangerous ingredient for any oral preparation that is likely to be used parenterally.