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CD antigens 2001.

D Y Mason1, P André, A Bensussan

  • 1Haematology Department, Nuffield Dept. of Clinical Laboratory Sciences, University of Oxford, Rm. 4734 John Radcliffe Hospital, Oxford OX3 9DU, UK. david.mason@ndcls.ox.ac.uk

Tissue Antigens
|April 4, 2002
PubMed
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The Human Leucocyte Differentiation Antigen Workshop established over 80 new CD specificities, expanding the catalog of cell surface markers. Future workshops will explore additional candidates and intracellular molecules for hematopoiesis research.

Area of Science:

  • Immunology
  • Cell Biology
  • Hematopoiesis

Background:

  • The 7th Human Leucocyte Differentiation Antigen Workshop (HLDA7) convened in 2000, focusing on identifying and characterizing novel cell surface molecules on human leukocytes.
  • New thematic sections were introduced, including Dendritic cells, Stem/progenitor cells, Erythroid cells, and Carbohydrate Structures, broadening the scope of leukocyte research.
  • Monoclonal antibodies with pre-existing molecular data were prioritized to streamline the identification of known specificities and accelerate the discovery of new ones.

Framework:

  • Established over 80 new CD (Cluster of Differentiation) specificities, significantly increasing the known repertoire of leukocyte surface antigens.
  • Published proceedings (Leucocyte Typing VII) detail these new specificities, providing a valuable resource for the scientific community.
  • Identified potential CD candidates for future workshops based on monoclonal antibody production and gene cloning data.

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Implementation:

  • Screening of monoclonal antibodies against known specificities was enhanced by selecting reagents with available molecular data.
  • Systematic characterization of leukocyte surface molecules led to the establishment of a substantial number of new CD designations.
  • Exploration of potential new CD candidates and intracellular molecules for future research initiatives.

Implications:

  • The expanded CD nomenclature facilitates more precise identification and classification of leukocyte subsets, crucial for understanding immune function and disease.
  • The identification of intracellular leukocyte-associated molecules opens new avenues for research into human hematopoietic cell biology.
  • Anticipates future advancements in leukocyte typing and the development of novel diagnostic and therapeutic strategies targeting specific cell populations.