Junctions as organizing centers in epithelial cells? A fly perspective
Thomas Lecuit1, Eric Wieschaus
1Howard Hughes Medical Institute, Molecular Biology Department, Washington Road, Princeton University, Princeton, New Jersey 08544, USA. lecuit@ibdm.Univ-mrs.fr
Abstract:
Junctions isolate the apical from the basal-lateral surfaces and are required for the polarization of epithelial cells. Genetics of junction formation in Drosophila has identified numerous transmembrane and scaffolding proteins that assemble in membrane-associated complexes. This review focuses on recent findings suggesting that junctions are autonomous organizing centers for the establishment and maintenance of apical-basal polarity in epithelial cells as well as other polarized processes such as the orientation of the division apparatus.
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