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Improved method for the quality assurance of [C-11]choline
E Mishani1, I Ben-David, Y Rozen
1Hebrew University, Hadassah Hospital, Department of Medical Biophysics and Nuclear Medicine, Il-91120, Jerusalem, Israel. mishani@md2.huji.ac.il
Nuclear Medicine and Biology
|April 4, 2002
Abstract:
[C-11]choline is a very promising radiomarker for the diagnosis of various human tumors using Positron Emission Tomography (PET). The existing quality control process for [C-11]choline is complicated and combines two HPLC methods with limited separation and sensitivity which prevent the accurate determination of the specific activity. We have developed a new efficient single HPLC method for the detection of choline chloride and dimethylaminoethanol with high resolution and sensitivity using cation-exchange chromatography.