Comparison of human ocular torsion patterns during natural and galvanic vestibular stimulation

Galvanic vestibular stimulation (GVS) is reported to induce interindividually variable tonic ocular torsion (OT) and superimposed torsional nystagmus. It has been proposed that the tonic component results from the activation of otolith afferents. We tested our hypothesis that both the tonic and the phasic OT are mainly due to semicircular canal (SCC) stimulation by examining whether the OT patterns elicited by GVS can be reproduced by pure SCC stimulations. Using videooculography we measured the OT of six healthy subjects while two different stimuli with a duration of 20 s were applied: 1) transmastoidal GVS steps of 2 mA with the head in a pitched nose-down position and 2) angular head rotations around a combined roll-yaw axis parallel to the gravity vector with the head in the same position. The stimulation profile was individually scaled to match the nystagmus properties from GVS and consisted of a sustained velocity step of 4-12 degrees /s on which a velocity ramp of 0.67-2 degrees /s(2) was superimposed. Since blinks were reported to induce transient torsional eye movements, the subjects were also asked to blink once 10 s after stimulus onset. Analysis of torsional eye movements under both conditions revealed no significant differences. Thus we conclude that both the tonic and the phasic OT responses to GVS can be reproduced by pure rotational stimulations and that the OT-related effects of GVS on SCC afferents are similar to natural stimulations at small amplitudes.