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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
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Gastrointestinal malformations, associated congenital abnormalities, and intrauterine growth

András Tárnok1, Károly Méhes

  • 1Department of Pediatrics, Faculty of Medicine, University of Pécs, Pécs, Hungary. andras.tarnok@aok.pte.hu

Journal of Pediatric Gastroenterology and Nutrition
|April 4, 2002
PubMed

Insights

Congenital gastrointestinal malformations are often linked to skeletal disorders and intrauterine growth retardation. These associations require further study but are crucial for patient care.

Area of Science:

  • Pediatric Surgery
  • Neonatology
  • Medical Genetics

Background:

  • Congenital gastrointestinal anomalies are understudied compared to other malformations.
  • Understanding associated conditions is vital for comprehensive care.

Purpose of the Study:

  • To analyze the prevalence of gastrointestinal malformations.
  • To investigate associated disorders and intrauterine growth.
  • To evaluate these factors in neonates admitted to a Neonatal Intensive Care Unit.

Main Methods:

  • Retrospective analysis of newborn infants (1987-2000).
  • Inclusion criteria: Neonatal Intensive Care Unit admission.
  • Focus on gastrointestinal malformations, associated disorders, and intrauterine growth.

Main Results:

  • 5.68% of neonates had gastrointestinal malformations (241/4241).
  • Skeletal disorders were the most common associated anomalies.
  • Intrauterine growth retardation affected 38.9% of isolated and 30.8% of multiple gastrointestinal malformations.

Conclusions:

  • Gastrointestinal malformations frequently coexist with skeletal anomalies and intrauterine growth retardation.
  • The interplay between these conditions warrants further investigation.
  • Clinical management should consider these common associations.
Abstract

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