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The relationship between paroxysmal kinesigenic choreoathetosis and epilepsy
1Department of Child Neurology, Okayama University Medical School, 2 - 5 - 1, Shikatacho Okayama, Japan.
Neuropediatrics
|April 4, 2002
Summary
Paroxysmal kinesigenic choreoathetosis (PKC) and epilepsy share a connection, with most patients showing epileptic discharges on EEG. This suggests a common cerebral cortex abnormality, particularly in frontal regions.
Area of Science:
- Neurology
- Clinical Neuroscience
- Epileptology
Background:
- Paroxysmal kinesigenic choreoathetosis (PKC) is a rare hyperkinetic movement disorder.
- The co-occurrence of PKC and epilepsy presents diagnostic and therapeutic challenges.
Purpose of the Study:
- To investigate the relationship between paroxysmal kinesigenic choreoathetosis (PKC) and epilepsy.
- To analyze clinical and electroencephalographic (EEG) findings in patients with both conditions.
Main Methods:
- Study included 15 patients (12 familial, 3 sporadic) with PKC and epilepsy.
- Long-term follow-up (average 16 years, 8 months).
- Analysis of 163 interictal and ictal EEGs.
Main Results:
- Transient epileptic discharges observed in 66.7% of patients.
- Centro-midtemporal and frontal spikes were the most common EEG findings.
- One patient exhibited a partial seizure with secondary generalization originating from the frontal area.
Conclusions:
- Patients with both PKC and epilepsy likely have a functional cerebral cortex abnormality.
- The perirolandic and frontal regions appear particularly involved.