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[Study on endothelial cell injury in women with pregnancy induced hypertension]
1Maternal and Children Health Center, First Hospital, Peking University, Beijing 100034, China.
Objective:
To investigate the mechanisms of endothelial cell injury in women with pregnancy induced hypertension (PIH).
Methods:
Human umbilical endothelial cells were cultured in the serum from 10 women with severe PIH and 10 normal pregnant women, and co-cultured with neutrophils or not for 48 hrs. The morphology and cell cycles were studied.
Results:
Without neutrophils, no apoptotic cells were observed, while neutrophils were added, apoptotic cells were obviously detected. The percentage of apoptotic cells in PIH was more than that in non-PIH. The percentage of cells in G2/M phase decreased in all the groups, but there were no significant differences among them.
Conclusions:
Endothelial cells were injured indirectly in PIH patients. Activated neutrophils induced apoptosis might be one of the answers.
