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Randomized clinical trials in pancreatic cancer
Alexander Stojadinovic1, Axel Hoos, Murray F Brennan
1Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA. ta.stojadinovic@verizon.net
Surgical Oncology Clinics of North America
|April 5, 2002
Summary
This review of pancreatic carcinoma trials found limited surgical research. Key areas explored included resection extent, lymph node dissection, and reconstruction methods, with some trials on palliative interventions.
Area of Science:
- Surgical Oncology
- Gastrointestinal Surgery
Background:
- Pancreatic carcinoma research has historically focused on limited surgical interventions.
- A comprehensive review of early surgical trials is essential for understanding treatment evolution.
Purpose of the Study:
- To systematically review prospective, randomized, controlled trials in pancreatic carcinoma published between 1977 and 2000.
- To analyze the scope and findings of surgical trials within this period.
Main Methods:
- A literature search identified 59 relevant trials.
- Eleven surgical trials were specifically analyzed for their methodologies and outcomes.
- Trials focused on resection extent, lymphadenectomy, pancreaticenteric reconstruction, and palliative procedures.
Main Results:
- Two trials compared standard versus pylorus-preserving pancreaticoduodenectomy.
- Two trials evaluated standard versus extended lymph node dissection.
- Five trials assessed different pancreaticenteric reconstruction techniques.
- Single trials examined prophylactic gastrojejunostomy and chemical splanchnicectomy for advanced disease.
Conclusions:
- The early surgical research in pancreatic carcinoma was limited in scope.
- Key surgical trial areas included resection, lymphadenectomy, and reconstruction.
- Further research is needed to advance surgical treatment for pancreatic cancer.