Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Developmental brain damage after chemically induced epileptic seizures.

European Neurology

|January 1, 1975

Summary

Repeated epileptic seizures induced by Flurothyl gas significantly reduced brain cell count in Wistar rats. After 10 days, a 17.6% decrease in brain cells was observed in seizure-treated subjects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Hyperthermia aggravates status epilepticus-induced epileptogenesis and neuronal loss in immature rats.

Neuroscience·2015

Same author

Advances in the pathophysiology of status epilepticus.

Acta neurologica Scandinavica. Supplementum·2007

Same author

Advances in the pathophysiology of status epilepticus.

Acta neurologica Scandinavica·2007

Same author

Mitochondrial pathways of neuronal necrosis.

Biochemical Society transactions·2006

Same author

Hypoxia in presence of blockers of excitotoxicity induces a caspase-dependent neuronal necrosis.

Neuroscience·2006

Same author

Urethane anesthesia produces selective damage in the piriform cortex of the developing brain.

Brain research. Developmental brain research·2001

Area of Science:

Neuroscience
Toxicology
Cell Biology

Background:

Epileptic seizures can impact brain structure.
Understanding the cellular effects of induced seizures is crucial for neurological research.

Purpose of the Study:

To investigate the impact of Flurothyl-induced epileptic seizures on brain cell numbers in Wistar rats.

Main Methods:

Wistar rats were administered Flurothyl twice daily to induce seizures.
Brain cell counts were compared between seizure-treated rats and control littermates over 5 and 10 days.

Main Results:

A 6% reduction in brain cells (5.2 million) was observed after 5 days of treatment.
A significant 17.6% reduction in brain cells (33.4 million) was noted after 10 days of treatment.

Conclusions:

Flurothyl-induced epileptic seizures lead to a progressive and substantial loss of brain cells in rats.
These findings highlight the neurotoxic potential of repeated seizures and their impact on brain cellularity.

Related Experiment Videos