Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

RNAi (Nematodes: Caenorhabditis elegans).

Alla Grishok1, Craig C Mello

  • 1Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01605, USA.

Advances in Genetics
|April 5, 2002
PubMed
Summary

RNA interference (RNAi) in Caenorhabditis elegans is a gene silencing process triggered by double-stranded RNA. This chapter explores RNAi

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Systematic Identification of Germ Granule Proteins Reveals Specialized Roles in RNAi and Small RNA Inheritance.

bioRxiv : the preprint server for biology·2026
Same author

Mutual regulation of spermatogenesis-specific Argonaute proteins and Insulin/IGF-1 signaling in aging control.

EMBO reports·2026
Same author

From nematode to Nobel: How community-shared resources fueled the rise of <i>Caenorhabditis elegans</i> as a research organism.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Resistance to Cry14A family Bacillus thuringiensis crystal proteins in Caenornabditis elegans operates via the nhr-31 transcription factor and vacuolar-type ATPase pathway.

PLoS pathogens·2024
Same author

DOT1L stimulates MYC/Mondo transcription factor activity by promoting its degradation cycle on chromatin.

bioRxiv : the preprint server for biology·2024
Same author

The CERV protein of Cer1, a C. elegans LTR retrotransposon, is required for nuclear export of viral genomic RNA and can form giant nuclear rods.

PLoS genetics·2023

Area of Science:

  • Molecular Biology
  • Genetics
  • Developmental Biology

Background:

  • RNA interference (RNAi) is a conserved biological process.
  • It functions as a homology-dependent gene silencing mechanism.
  • RNAi is induced by double-stranded RNA (dsRNA).

Purpose of the Study:

  • To provide a comprehensive overview of RNA interference (RNAi) in Caenorhabditis elegans.
  • To detail the history, characteristics, and molecular mechanisms of RNAi.
  • To explore the connections between RNAi and other silencing pathways.

Main Methods:

  • Review of historical discoveries and research findings.
  • Analysis of RNAi-deficient mutants in C. elegans.
  • Discussion of characterized components and molecular mechanisms of the RNAi pathway.

Main Results:

  • RNAi is a systemic, heritable process in C. elegans.
  • It is linked to co-suppression and transcriptional gene silencing.
  • Key components and the molecular mechanism of RNAi have been elucidated.

Conclusions:

  • RNA interference is a fundamental gene regulation mechanism in C. elegans.
  • Understanding RNAi provides insights into gene silencing pathways.
  • RNAi likely plays roles in development and immunity.

Related Experiment Videos