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Searching for the mountains of the moon: genome scans for atherosclerosis

Michael A Province1

  • 1Division of Biostatistics, Washington University School of Medicine, 660 South Euclid, Box 8067, St. Louis, MO 63110, USA. mike@wubios.wustl.edu

Current Atherosclerosis Reports
|April 5, 2002
PubMed

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...