Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Painful Peripheral Neuropathy.

Gil I. Wolfe1, Richard J. Barohn

  • 1*Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8897, USA. sharon.nations@utsouthwestern.edu

Current Treatment Options in Neurology
|April 5, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peripheral Neuropathy Due to Leprosy.

Current treatment options in neurology·2002
Same author

Peripheral Neuropathy Due to Cobalamin Deficiency.

Current treatment options in neurology·2002
Same author

Thymectomy for Myasthenia Gravis.

Current treatment options in neurology·2002
Same author

Diabetic Lumbosacral Polyradiculoneuropathies.

Current treatment options in neurology·2001
Same journal

Visual Impairment and Driving in Older Adults: A Narrative Review.

Current treatment options in neurology·2026
Same journal

Non-Cognitive Symptoms in Alzheimer's Disease and Their Likely Impact on Patient Outcomes. A Scoping Review.

Current treatment options in neurology·2026
Same journal

Update on the Treatment of Autonomic Disorders.

Current treatment options in neurology·2025
Same journal

Primary Progressive Aphasia Treatment: Current Treatment Options in Neurology Article Topic: Management of Primary Progressive Aphasia.

Current treatment options in neurology·2025
Same journal

Emerging Principles for Treating Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD).

Current treatment options in neurology·2025
Same journal

Diagnosis and Management of Progressive Corticobasal Syndrome.

Current treatment options in neurology·2025
See all related articles

Managing neuropathic pain involves identifying its cause and using medications like tricyclic antidepressants and anticonvulsants. Individualized treatment plans, including monotherapy or polypharmacy, benefit most patients with painful peripheral neuropathies.

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Neuropathic pain is a significant symptom in various peripheral neuropathies, including those linked to diabetes, uremia, HIV, and alcohol abuse.
  • Pain is also prevalent in idiopathic sensory and sensorimotor polyneuropathies, affecting a majority of patients.

Purpose of the Study:

  • To review current pharmacologic approaches for treating neuropathic pain.
  • To highlight first-line pharmacologic agents and individualized treatment strategies.

Main Methods:

  • Review of available pharmacologic agents for neuropathic pain.
  • Focus on medications with rigorous study, specifically tricyclic antidepressants and anticonvulsants.
  • Emphasis on identifying the etiology of neuropathy and tailoring therapy.

Related Experiment Videos

Main Results:

  • Tricyclic antidepressants and anticonvulsants are widely used and considered first-line agents.
  • Individualized pharmacotherapy is crucial due to potential adverse events and variable patient responses.
  • Monotherapy or rational polypharmacy can benefit the majority of patients.

Conclusions:

  • Effective management of neuropathic pain requires identifying the underlying cause and selecting appropriate pharmacologic agents.
  • Individualized treatment, considering tolerability and mechanism of action, is key to successful pain management.
  • A majority of patients can achieve pain relief through well-chosen monotherapy or combination drug regimens.