Remodeled-matrix contraction by fibroblasts: numerical investigations

It is well known that the fibroblast-collagen-matrix contraction model is a unique way to study mechanical interactions that regulate wound contraction of connective tissue cells. This contraction, due to cell traction, plays important roles in wound healing and pathological contractures. A continuum model initially used for the study of mesenchymal morphogenesis is revisited and numerically investigated by assuming that the extracellular matrix has adaptive-elastic properties. The set of non-linear partial differential equations is solved numerically by a finite difference method and the obtained results are discussed.