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Related Experiment Videos

NAADP: an atypical Ca2+-release messenger?

Armando A Genazzani1, Richard A Billington

  • 1Dept of Pharmacology, University of Cambridge, Tennis Court Road, CB2 1PD, Cambridge, UK. aag25@cam.ac.uk

Trends in Pharmacological Sciences
|April 5, 2002
PubMed
Summary

Nicotinic acid adenine dinucleotide phosphate (NAADP) mobilizes intracellular calcium stores across diverse species. This molecule may coordinate calcium signaling pathways and its receptor desensitization is being investigated.

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Area of Science:

  • Cellular biology
  • Biochemistry
  • Physiology

Background:

  • Nicotinic acid adenine dinucleotide phosphate (NAADP) is an endogenous signaling molecule.
  • NAADP is known to mobilize intracellular calcium (Ca2+) stores.

Purpose of the Study:

  • To investigate the role of NAADP in intracellular Ca2+ signaling.
  • To explore the potential of NAADP in coordinating Ca2+-releasing messengers.
  • To understand the mechanisms of NAADP receptor desensitization.

Main Methods:

  • Utilized various experimental techniques to study NAADP.
  • Employed radioligand binding assays to investigate receptor desensitization.

Main Results:

  • NAADP mobilizes intracellular Ca2+ stores in a wide range of cell types, including invertebrate, lower vertebrate, plant, and mammalian cells.

Related Experiment Videos

  • Evidence suggests NAADP may play a unique role in coordinating Ca2+ signaling.
  • Radioligand binding experiments provided insights into NAADP receptor desensitization.

    • Conclusions:

    • NAADP is a widespread intracellular Ca2+ mobilizing messenger.
    • NAADP may act as a coordinator of complex Ca2+ signaling networks.
    • Understanding NAADP receptor desensitization is crucial for elucidating its physiological roles.