Macrophage migration inhibitory factor (MIF): mechanisms of action and role in disease
Hongqi Lue1, Robert Kleemann, Thierry Calandra
1Laboratory of Biochemistry, Institute for Interfacial Engineering, University of Stuttgart, 70569 Stuttgart, Germany.
Microbes and Infection
|April 5, 2002
Abstract:
Macrophage migration inhibitory factor (MIF) is a unique cytokine and critical mediator of host defenses with a role in septic shock and chronic inflammatory and autoimmune diseases. Its mechanism of action is incompletely understood. Here, we attempt to correlate current knowledge on the molecular pathways of MIF activity with its functions in immunity and disease.


