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Published on: February 9, 2016
Beta-blockers, exercise, and the immune system in men with coronary artery disease
Michael Sagiv1, David Ben-Sira, Ehud Goldhammer
1The Sports Medicine and Rehabilitation Division, The Zinman College of Physical Education, Wingate Institute, Netanya 42902, Israel. sagiv@wincol.macam98.ac.il
Purpose:
The purpose of the present study was to examine the effect of aerobic exercise training on the immune system in coronary artery disease patients treated with beta-blockers.
Methods:
Twenty-five patients (46.1 +/- 2 yr) treated with atenolol, a beta-blocker agent, for 3 months before exercising were divided randomly into two groups: 15 underwent an aerobic exercise training program for 12 wk at 65-70% of their work capacity, whereas the other 10 patients served as controls.
Results:
After training, levels of CD4 and CD8 cells were significantly (P < 0.05) higher and concomitantly the CD4/CD8 ratio decreased significantly (P < 0.05) in the exercising group compared with the control group.
Conclusions:
Data suggest that coronary artery disease patients exercising aerobically at 65-70% of their work capacity gain a statistically significant higher lymphocyte T cell function as compared with their untrained counterparts.
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