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Synthesis and reactivity of an alpha-stannyl beta-silyl enamide
Laurianne Timbart1, Jean-Christophe Cintrat
1CEA/Saclay, Service des Molécules Marquées Bât. 547, Département de Biologie Cellulaire et Moléculaire 91191 Gif sur Yvette cedex, France.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|April 5, 2002
Abstract:
We describe here an unprecedented approach to the synthesis of stereodefined 1,2-bis-substituted enamides. Starting from bis-metallated enamides, a palladium-copper coupling reaction allows the introduction of various groups at C1, whilst iododesilylation affords a new entry for the functionalization at C2.