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Varidase: the science behind the medicament.

P M Rutter¹, B Carpenter, S S Hill

¹School of Pharmacy and Biomedical Science, University of Portsmouth, Portsmouth, Hants, UK.

Journal of Wound Care

|April 6, 2002

Summary

Varidase, containing streptokinase and streptodornase, treats wounds effectively. Research focuses on improving quality assessment for this topical enzyme therapy, ensuring better wound care outcomes.

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Area of Science:

Biochemistry
Wound Healing
Pharmaceutical Sciences

Background:

Varidase is a globally used topical treatment for purulent and suppurating wounds.
Its therapeutic action relies on the enzymes streptokinase and streptodornase.
These active enzymes constitute a minor fraction of the overall bulked solid in Varidase preparations.

Purpose of the Study:

To provide an overview of Varidase preparation and its mechanism of action.
To highlight research and development efforts in enhancing the quality and composition assessment of Varidase.

Main Methods:

Literature review on Varidase preparation and enzymatic activity.
Analysis of research advancements in quality control methodologies.
Discussion of formulation and analytical techniques for enzyme assessment.

Main Results:

Varidase efficacy is attributed to streptokinase and streptodornase enzymes.
Significant R&D has been invested in refining quality assessment protocols.
Improved methods ensure consistent potency and purity of the active components.

Conclusions:

Varidase remains a key therapeutic agent for specific wound types.
Ongoing research ensures the quality and reliability of Varidase through advanced assessment techniques.
Enhanced quality control contributes to improved patient outcomes in wound management.

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