The effects of radiotherapy on maxillofacial tissue

Radiation therapy for the treatment of maxillofacial tumours can lead to delayed complications. One of the most severe complications is osteoradionecrosis (ORN), which can cause orocutaneous fistulae, exposed mandible and considerable pain. The condition can occur years after radiotherapy and requires aggressive prevention and treatment. Hyperbaric oxygen therapy has been found beneficial for patients with maxillofacial ORN, leading to pain relief, fistula closure and bone coverage.