Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Lymphoproliferative disease after transplantation].

L Boudová1, F Fakan, M Michal

  • 1Siklův patologicko-anatomický útav, Lékarská fakulta Univerzity Karlovy a Fakultní nemocnice, Plzen. boudova@fnplzen.cz

Ceskoslovenska Patologie
|April 6, 2002
PubMed
Summary

Posttransplantation lymphoproliferative disease (PTLD) affects organ transplant recipients, often linked to Epstein-Barr virus (EBV). Treatment involves reduced immunosuppression and chemotherapy, but outcomes remain challenging, with significant mortality.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effects of surface heterogeneity on erosion and sedimentation and their implications for of soil properties at postmining sites.

The Science of the total environment·2024
Same author

Hepatic pseudolymphoma: a surprising finding in a case with suspected generalisation of lung cancer.

Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti·2020
Same author

Abdominal aortic aneurysm as an IgG4-related disease.

Clinical and experimental immunology·2019
Same author

A prospective multicenter trial on sentinel lymph node biopsy in patients with early-stage cervical cancer (SENTIX).

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2019
Same author

Transabdominal two-cavity approach for radical nephrectomy combined with inferior vena cava thrombectomy for malignant thrombus caused by renal cell carcinoma: a case series.

Journal of medical case reports·2018
Same author

Acid rain footprint three decades after peak deposition: Long-term recovery from pollutant sulphate in the Uhlirska catchment (Czech Republic).

The Science of the total environment·2017

Area of Science:

  • Immunology
  • Oncology
  • Transplantation Medicine

Context:

  • Posttransplantation lymphoproliferative disease (PTLD) is a serious complication following solid organ and hematopoietic stem cell transplantation.
  • PTLD arises from the proliferation of lymphoid cells, often associated with Epstein-Barr virus (EBV) infection.
  • Understanding PTLD pathogenesis and clinical course is crucial for improving patient outcomes.

Purpose:

  • To report on 7 cases of PTLD, detailing their clinical characteristics, diagnostic findings, and treatment outcomes.
  • To investigate the association of PTLD with EBV and specific PTLD subtypes (monomorphic and polymorphic).
  • To evaluate the efficacy of current treatment strategies, including immunosuppression reduction, chemotherapy, and surgery.

Summary:

Related Experiment Videos

  • Seven PTLD cases (kidney, kidney-pancreas, heart, stem cell recipients) aged 25-62 were analyzed, occurring 4 months to 12 years post-transplant.
  • Cases included monomorphic (4) and polymorphic (3) PTLD, with EBV detected in some via immunohistochemistry and PCR.
  • Monoclonal immunoglobulin heavy chain gene rearrangement was identified in three cases.
  • Treatment involved immunosuppression adjustment, chemotherapy, and surgery; mortality was high, primarily due to infections.

    • Impact:

    • This case series highlights the diverse clinical presentations and challenging prognosis of PTLD.
    • Findings underscore the importance of EBV status in PTLD development and management.
    • The study emphasizes the need for optimized therapeutic strategies to improve survival rates in transplant recipients with PTLD.