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Melanoma Cell Adhesion Molecule (MCAM) expression in the myogenic lineage during early chick embryonic development
Cristina Pujades1, Borhane Guez-Guez, Dominique Dunon
1CNRS UMR7622, Université Pierre et Marie Curie, Paris, France. cpujades@snv.jussieu.fr
The International Journal of Developmental Biology
|April 6, 2002
Abstract:
We describe the expression pattern of cMCAM, a cell adhesion molecule of the immunoglobulin superfamily, in early chick embryonic development by in situ hybridisation. An initial ectodermal domain of expression is subsequently expanded, and cMCAM is expressed in the neural crest cells, otic vesicle, heart primordium, notochord and endoderm. In addition, cMCAM expression localises in the myotome once the somite cells have been specified. An in vitro murine cellular system allowed us to confirm that MCAM expression coincides with the onset of myogenic cell determination.