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Related Experiment Videos

Jaundice due to carbimazole.

M Lunzer, S N Huang, J Ginsburg

    Gut
    |November 1, 1975
    PubMed
    Summary

    Carbimazole, a medication for hyperthyroidism, caused liver injury in a patient, presenting with fever, jaundice, and elevated liver enzymes. Liver biopsy confirmed drug-related liver damage, highlighting potential adverse effects of this common treatment.

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    Area of Science:

    • Hepatology
    • Clinical Pharmacology
    • Internal Medicine

    Background:

    • Hyperthyroidism is a common endocrine disorder often treated with antithyroid medications.
    • Carbimazole is a widely prescribed drug for managing hyperthyroidism.
    • Drug-induced liver injury (DILI) is a significant concern in pharmacotherapy.

    Observation:

    • A 63-year-old woman experienced recurrent symptoms including fever, pruritus, malaise, and jaundice after carbimazole use.
    • A drug challenge with carbimazole precipitated acute symptoms and elevated liver enzymes.

    Findings:

    • Liver biopsy revealed changes consistent with drug-induced liver injury.
    • Electron microscopy showed fine structural alterations indicative of toxicity.

    Implications:

    • Carbimazole can be associated with significant hepatotoxicity.
    • Physicians should consider carbimazole-induced liver injury in patients with unexplained liver dysfunction.
    • This case highlights the importance of vigilant monitoring for adverse drug reactions.

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