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Related Experiment Videos

Neotame anhydrate polymorphs I: preparation and characterization.

Zedong Doug1, Brian E Padden, Jonathon S Salsbury

  • 1Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis 55455-0343, USA.

Pharmaceutical Research
|April 6, 2002
PubMed
Summary

Seven polymorphs of neotame anhydrate were prepared and characterized. These crystalline forms exhibit distinct properties, including varying stability and water vapor sorption, suggesting conformational polymorphism.

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Area of Science:

  • Solid-state chemistry
  • Crystallography
  • Materials science

Background:

  • Neotame is a high-intensity artificial sweetener.
  • Understanding the polymorphic behavior of neotame anhydrate is crucial for its formulation and stability.

Purpose of the Study:

  • To synthesize and characterize different polymorphic forms of neotame anhydrate.
  • To compare the properties of these polymorphs.

Main Methods:

  • Polymorphs were prepared via crystallization, suspension, or dehydration.
  • Characterization involved techniques such as DSC, TGA, PXRD, 13C SSNMR, FTIR, SEM, and dynamic vapor sorption.

Main Results:

  • Seven distinct neotame anhydrate polymorphs (Forms A-G) were successfully prepared.

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  • Two enantiotropic pairs (B/C and E/A) were identified.
  • Polymorphs exhibited differences in thermal properties, PXRD patterns, water vapor sorption, and density, with SSNMR suggesting conformational variations.

    • Conclusions:

    • Neotame anhydrate polymorphs display conformational polymorphism.
    • Less dense forms, crystallized from more polar solvents, showed reduced water vapor sorption.
    • Two enantiotropic relationships were confirmed among the identified polymorphs.