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Novel matrix metallo-proteinase (MMP-2) phosphonoboronate inhibitors
Inna Pergament1, Reuven Reich, Morris Srebnik
1Department of Medicinal Chemistry and Natural Products, Hebrew University in Jerusalem, POB 12065, 91120, Jerusalem, Israel.
Bioorganic & Medicinal Chemistry Letters
|April 6, 2002
Abstract:
A series of novel phosphonoboronates consisting of PC(1)B, PC(n)B, PC(X)C(n)B, and PCC=CB derivatives were evaluated as MMP-2 inhibitors. Structure-activity relationships (SARs) data for the compounds were discovered and are discussed.