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Neurobehavioural testing in workers occupationally exposed to lead: systematic review and meta-analysis of

M Goodman1, N LaVerda, C Clarke

  • 1Exponent Health Group, Alexandria, VA 22314, USA. mgoodman@exponent.com

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|April 6, 2002
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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...