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Related Experiment Videos

Inflammation and stroke: the Leiden 85-Plus Study .

E van Exel1, J Gussekloo, A J M de Craen

  • 1Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, Netherlands.

Stroke
|April 6, 2002
PubMed
Summary
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Low interleukin-10 (IL-10) production is linked to a higher risk of stroke. This study found that individuals with lower IL-10 levels had an increased likelihood of both a stroke history and fatal stroke events.

Area of Science:

  • Immunology
  • Neurology
  • Cardiovascular Medicine

Background:

  • Interleukin-10 (IL-10) deficiency is implicated in cardiovascular and cerebrovascular diseases.
  • This study investigates the association between reduced IL-10 production, stroke history, and incident fatal stroke.

Purpose of the Study:

  • To analyze the relationship between low IL-10 production levels and the risk of stroke.
  • To determine if IL-10 levels predict incident fatal stroke.

Main Methods:

  • 85-year-old inhabitants of Leiden, Netherlands (n=599) were assessed.
  • Interleukin-10 (IL-10) production was measured via whole blood assay.
  • C-reactive protein (CRP) levels and stroke history were recorded; fatal strokes were followed prospectively.

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Main Results:

  • Subjects with a stroke history had significantly lower IL-10 levels and higher CRP concentrations.
  • Low IL-10 production levels were associated with an increased odds ratio for a history of stroke (OR=2.30).
  • The relative risk for incident fatal stroke was higher in subjects with low or intermediate IL-10 levels (RR=2.94).

Conclusions:

  • The findings support the hypothesis that low IL-10 production levels increase stroke risk.
  • Reduced IL-10 may serve as a biomarker for stroke risk assessment.