Fate of 2,5,4'-trichlorobiphenyl in rats

1. Following the administration of daily oral doses (1 mg/kg) of 2,5,4'-trichloro-[14C]biphenyl to rats for 14 days, the compound was rapidly excreted, only small amounts (3--4%) being stored in the organs. 2. The majority of the biphenyl was metabolized (greater than 85%) and the major metabolites excreted were identified as hydroxy-, dechloro- and conjugated derivatives.