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Miniature surface-plasmon resonance immunosensors--rapid and repetitive procedure
Masayasu Suzuki1, Fumihiko Ozawa, Wakako Sugimoto
1Department of Electric and Electronic Engineering, Toyama University, Japan.
Analytical and Bioanalytical Chemistry
|April 9, 2002
Abstract:
Miniaturized immunosensors based on surface-plasmon resonance (SPR) have been developed by using the sensor recently developed by Texas Instruments. By using this sensor for human immunoglobulin G (IgG) rapid and repetitive measurements could be performed by alternate injection of sample and glycine-HCl buffer. A sensor for human serum albumin (HSA) could also be developed similarly. One difficulty in immunosensor development is dissociation of the strongly bound antigen-antibody complex. A "regenerable" immunosensor has also been developed for this reason.