Related Experiment Video

Updated: Aug 9, 2026

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)
11:35

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)

Published on: August 21, 2016

Polymorphism of the thymidylate synthase gene and outcome of acute lymphoblastic leukaemia

M Krajinovic1, I Costea, S Chiasson

  • 1Service d'Hématologie-Oncologie, Centre de Recherche, Hôpital Sainte-Justine, 3175 Côte Ste-Catherine, Quebec H3T 1C5, Montreal, Canada. maja.krajinovic@umontreal.ca

Lancet (London, England)
|April 9, 2002
PubMed

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...