Related Experiment Videos
Efficient synthesis of 'redox-switched' naphthoquinone thiol-crown ethers and their biological activity evaluation
Sheng Tung Huang1, Hsien Shou Kuo, Chiao Long Hsiao
1Department of Biochemistry, Taipei Medical University, Taipei, Taiwan.
Bioorganic & Medicinal Chemistry
|April 9, 2002
Abstract:
Series of naphthoquinone thiol-crown ethers had been prepared. The antibacterial, antifungal, and cytotoxic activities of these synthetic naphthoquinone thiol-crown ethers were investigated. All of the compounds tested displayed antibacterial, cytotoxic and antifungal activities. The bis-naphthoquinone thiol-crown ether 7a was the most potent inhibitor among tested analogues against Staphylococcus aureus methicillin resistance with MIC value of 2.68 microM.