Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gene responses to hyperglycaemia.

David W P Lappin1, Peter Doran, Catherine Godson

  • 1Department of Medicine and Therapeutics, Mater Misericordiae Hospital, Conway Institute of Biomolecular and Biomedical Research, University College of Dublin, 41 Eccles Street, Dublin 7, Ireland.

Experimental Nephrology
|April 9, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response to the Letter to the Editor Entitled "A Missing Genomic Dimension: The Small but Central Mitochondrial Genome in Diabetic Kidney Disease Genetics".

Kidney international reports·2026
Same author

Diagnostic and Clinical Utility of Assessing Renal Functional Reserve: Unmasking Subclinical Kidney Disease.

Kidney360·2026
Same author

Quantifying the carbon footprint of clinical research activities - measurement tools and methods: a scoping review protocol.

HRB open research·2026
Same author

Co-developing a survey on public understanding of sustainable clinical research: A study protocol.

PloS one·2026
Same author

Goals and trends in space exploration: An overview of the panel on exploration sessions at the committee on space research general assembly 2024.

Life sciences in space research·2026
Same author

Tandem RNA and Protein Extraction: A Platform for Maximizing the Use of Limited Ex Vivo Tissue Samples.

Bio-protocol·2026
Same journal

Mixed bone marrow or mixed stem cell transplantation for prevention or treatment of lupus-like diseases in mice.

Experimental nephrology·2002
Same journal

Segregation of experimental autoimmune glomerulonephritis as a complex genetic trait and exclusion of Col4a3 as a candidate gene.

Experimental nephrology·2002
Same journal

Activation of peroxisome proliferator-activated receptor-gamma inhibits apoptosis induced by serum deprivation in LLC-PK1 cells.

Experimental nephrology·2002
Same journal

Characterization of adenosine receptors in human kidney proximal tubule (HK-2) cells.

Experimental nephrology·2002
Same journal

Altered renin synthesis and secretion in the kidneys of heterozygous mice with a null mutation in the TGF-beta(2) gene.

Experimental nephrology·2002
Same journal

Induction of alpha-catenin, integrin alpha3, integrin beta6, and PDGF-B by 2,8-dihydroxyadenine crystals in cultured kidney epithelial cells.

Experimental nephrology·2002
See all related articles

Diabetic nephropathy (DN) molecular mechanisms are key to new treatments. Gene subtraction techniques reveal novel players and signaling pathways influenced by high glucose, offering new therapeutic targets for kidney disease.

Area of Science:

  • Nephrology
  • Molecular Biology
  • Genomics

Background:

  • Diabetic nephropathy (DN) presents a significant clinical challenge.
  • Understanding the molecular basis of DN is crucial for developing new diagnostics and therapeutics.

Purpose of the Study:

  • To review molecular mediators of tissue injury in DN.
  • To highlight novel molecular players identified using gene subtraction techniques.
  • To summarize cell signaling events in DN and their therapeutic potential.

Main Methods:

  • Review of growth factors and cytokines.
  • Application of gene subtraction techniques (e.g., differential-display PCR, suppression-subtractive hybridization, nucleotide micro-arrays).

Main Results:

Related Experiment Videos

  • Identification of major growth factors and cytokines involved in DN.
  • Discovery of new molecular players through advanced genomic technologies.
  • Elucidation of high glucose-triggered cell signaling pathways influencing gene expression in DN.

Conclusions:

  • Gene subtraction technologies have significantly advanced the identification of DN molecular players.
  • Cell signaling pathways activated by high glucose are critical therapeutic targets for DN.
  • Further research into these molecular events will drive novel diagnostic and therapeutic strategies for DN.