Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Genes involved in atherosclerosis.

Johanna Laukkanen¹, Seppo Ylä-Herttuala

¹A.I. Virtanen Institute, University of Kuopio, PO Box 1627, FIN-70211 Kuopio, Finland.

Experimental Nephrology

|April 9, 2002

Summary

Atherosclerosis involves multiple genes and proteins affecting the arterial wall. This review focuses on key molecular players like lipoprotein receptors and cytokines in disease development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

AAV2-VEGF-B gene therapy failed to induce angiogenesis in ischemic porcine myocardium due to inflammatory responses.

Gene therapy·2022

Same author

Antiadenovirus Antibodies Predict Response Durability to Nadofaragene Firadenovec Therapy in BCG-unresponsive Non-muscle-invasive Bladder Cancer: Secondary Analysis of a Phase 3 Clinical Trial.

European urology·2021

Same author

Adenoviral VEGF-B186R127S gene transfer induces angiogenesis and improves perfusion in ischemic heart.

iScience·2021

Same author

SUR1-E1506K mutation impairs glucose tolerance and promotes vulnerable atherosclerotic plaque phenotype in hypercholesterolemic mice.

PloS one·2021

Same author

Functional roles of the membrane-associated AAV protein MAAP.

Scientific reports·2021

Same author

Finnish Society of Gene and Cell Therapy: A Visionary and Creative Player in the Field.

Human gene therapy·2021

Area of Science:

Cardiovascular Biology
Molecular Medicine

Background:

Atherosclerosis is a complex, multifactorial disease.
It involves intricate interactions within the arterial wall.

Purpose of the Study:

To review the role of specific molecular factors in atherogenesis.
Focus on the arterial wall's molecular mechanisms.

Main Methods:

Literature review of scientific articles.
Synthesis of information on key genes and proteins.

Main Results:

Lipoprotein receptors play a crucial role in lipid metabolism and arterial wall uptake.
Growth factors, cytokines, and chemokines modulate inflammation and cell proliferation.
Matrix metalloproteinases and adhesion molecules contribute to plaque instability and remodeling.
Apoptosis genes are involved in cell death within atherosclerotic lesions.

Conclusions:

Multiple molecular pathways, including lipoprotein receptors, growth factors, cytokines, chemokines, matrix metalloproteinases, adhesion molecules, and apoptosis genes, are integral to atherogenesis.
Understanding these factors is key to developing targeted therapies for atherosclerosis.

Related Experiment Videos