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Blood coagulation studies in children with surface hemangiomas
International Surgery
|October 1, 1975
Summary
Surface hemangiomas in children may involve a subtle, chronic "consumption coagulopathy." While standard clotting tests were normal, specific markers showed differences, suggesting localized blood changes in hemangiomas.
Area of Science:
- Pediatric Hematology
- Vascular Anomalies
- Coagulation Disorders
Background:
- Surface hemangiomas are common vascular tumors in children.
- The potential for associated coagulopathy, particularly latent forms, requires investigation.
Purpose of the Study:
- To investigate latent coagulopathy in pediatric patients with surface hemangiomas.
- To compare coagulation parameters between children with hemangiomas and healthy controls.
Main Methods:
- Evaluated 30 patients with surface hemangiomas.
- Assessed whole blood clotting time, kaolin cephalin clotting time, prothrombin time, thrombin time, and platelet counts.
- Measured plasma fibrinogen, euglobulin lysis time, and serum fibrinogen degradation products.
Main Results:
- Standard coagulation tests and platelet counts showed no significant difference compared to controls.
- Plasma fibrinogen, euglobulin lysis time, and fibrinogen degradation products had mean values significantly different from healthy children, despite remaining within normal ranges.
- These subtle alterations suggest localized hemostatic system activation.
Conclusions:
- Findings suggest a possible chronic, incipient 'consumption coagulopathy' localized within the hemangioma.
- Further research is warranted to elucidate the precise mechanisms and clinical implications of these localized coagulation changes.